Understanding AS01 Adjuvant Mode of Action in Vaccines
The use of adjuvants is required in some vaccine formulations to provide help to the antigen in order to enhance the immune response.1
Following induction of different adjuvants into vaccines in the 90’s, the need to combine adjuvants in so called adjuvant systems to enhance immunogenicity became apparent.2 The following video will highlight the mode of action of one specific adjuvant system: AS013-8:
References
- Garcon N, Leroux-Roels G, Cheng WF. Vaccine adjuvants. Understanding modern vaccines: perspectives in vaccinology. Elsevier; 2011. p. 89–113.
- Laupèze, B., Hervé, C., Di Pasquale, A., Tavares Da Silva, F. Adjuvant Systems for vaccines: 13 years of post-licensure experience in diverse populations have progressed the way adjuvanted vaccine safety is investigated and understood. Vaccine, 2019, 37(38), pp. 5670–5680.
- Didierlaurent AM, Collignon C, Bourguignon P, et al. Enhancement of adaptive immunity by the human vaccine adjuvant AS01 depends on activated dendritic cells. J Immunol 2014; 193:1920–1930.
- Leo O, Cunningham A & Stern PL. Vaccine Immunology. Understanding Modern Vaccines: Perspectives in Vaccinology. Elsevier vol.2011; 25–59.
- Dendouga N, Fochesato M, Lockman L, et al. Cell-mediated immune responses to a varicella-zoster virus glycoprotein E vaccine using both a TLR agonist and QS21 in mice. Vaccine 2012; 30:3126–3135.
- Geissmann F, Manz MG, Jung S, et al. Development of monocytes, macrophages, and dendritic cells. Science 2010; 327:656–661.
- Rezk SA & Weis L. Lymph Nodes. John Wiley & sons. Available at : https://onlinelibrary.wiley.com/doi/10.1002/9780470015902.a0000525.pub3. 2015.
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NX-GBL-GVX-WCNT-220016 | November 2022