Adjuvants Mode of Action in Vaccines
A greater understanding of the role of the innate response in eliciting specific adaptive immunity has led to an increased knowledge of the role of adjuvants in vaccine formulation. Adjuvants enhance and modulate the immune response to antigens by mimicking natural immune defense triggers.2
Adjuvants as explained in the video below can be key contributors in developing efficacious vaccines aiming to deliver enhanced and sustained protection.2-5
References
Leo O et al. In: Garçon N et al. Understanding Modern Vaccines, Perspectives in Vaccinology. Amsterdam: Elsevier; 2011. Vol 1. Chapter 2:25–59. Garçon N et al. In: Garçon N et al. Understanding Modern Vaccines, Perspectives in Vaccinology. Amsterdam: Elsevier; 2011. Vol 1. Chapter 4:89–113. Giannini SL et al. Enhanced humoral and memory B cellular immunity using HPV16/18 L1 VLP vaccine formulated with the MPL/aluminium salt combination (AS04) compared to aluminium salt only. Vaccine 2006;24:5937–49. Roman F et al. Effect on cellular and humoral immune responses of the AS03 adjuvant system in an A/H1N1/2009 influenza virus vaccine administered to adults during two randomized controlled trials. Clin Vaccine Immunol 2011;18:835–43. Roteli-Martins et al. Sustained immunogenicity and efficacy of the HPV-16/18 AS04-adjuvanted vaccine. Hum Vaccin Immunother 2012;8:390–397.
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NX-GBL-GVX-WCNT-220017 | November 2022